Demographic and clinical features of inclusion body myositis in north America
نویسندگان
چکیده
منابع مشابه
Demographic and clinical features of inclusion body myositis in North America.
INTRODUCTION Few studies of the demographics, natural history, and clinical management of inclusion body myositis (IBM) have been performed in a large patient population. To more accurately define these characteristics, we developed and distributed a questionnaire to patients with IBM. METHODS A cross-sectional, self-reporting survey was conducted. RESULTS The mean age of the 916 participan...
متن کاملClinical features of Japanese patients with inclusion body myositis.
BACKGROUND The incidence of sporadic inclusion body myositis (sIBM) has been much lower in Japanese than in Western populations. Because of a few reports on Asian populations, it is unclear whether the clinical characteristics of sIBM are identical in Caucasian and Japanese patients. METHODS We compared 18 patients with sIBM, divided into 3 groups by age-of-onset, with previous cohort studies...
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Inclusion-body myositis is the most frequent and disabling myopathy seen in patients over 50 years of age. The distinct clinical features that lead to correct diagnosis and inclusion-body myositis mimics are highlighted. Inclusionbody myositis has a complex pathogenesis in which autoimmune and inflammatory features coexist with elements of degeneration and abundant accumulations of various stre...
متن کاملInclusion Body Myositis
Inclusion body myositis is an insidious, slowly progressive myopathy of middle-aged and older individuals. Because of these characteristics, diagnosis is often delayed. Affected muscle is marked by the presence of rimmed vacuoles, inclusions, and an inflammatory infiltrate largely made up of CD8 T lymphocytes and macrophages. The inclusions contain beta-amyloid and phosphorylated tau protein, a...
متن کاملInclusion body myositis.
The histochemical and ultrastructural study of muscle biopsies of two patients with a chronic muscle weakness and wasting showed particular changes in muscle fibers: (1) peripheral lined vacuoles, containing whorls of membranes and cytoplasmic debris; (2) collections of intranuclear and intrasarcoplasmic tubular filaments (16-18 nm in external diameter and 6.5 nm in inner diameter). These chang...
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ژورنال
عنوان ژورنال: Muscle & Nerve
سال: 2015
ISSN: 0148-639X
DOI: 10.1002/mus.24562